| Organisation of 112th edition | |
| Category | ME (Men Elite) |
| Class | 1.UWT () |
| Organiser | - |
| Director | - |
| Timer | - |
Route |
| 20 March 2021 (Saturday) | ||
| Profile |  |
One-day race |
| Start |  |
Milan |
| Finish | |
Sanremo |
| Distance | 299.0 km (185.8 mi) | |
| Speed | 45.064 km/h (28.002 mi/h) | |
Results (Top 10) |
| # |  |
Rider | Age | Team | Time | Gap | ||
| 1 | 237 |  |
Stuyven, Jasper | 28 |  |
Trek - Segafredo | 6h 38' 06'' | |
| 2 | 154 |  |
Ewan, Caleb | 26 | |
Lotto - Soudal | 6h 38' 06'' | + 00' 00'' |
| 3 | 1 | |
Aert, Wout van | 26 |  |
Team Jumbo - Visma | 6h 38' 06'' | + 00' 00'' |
| 4 | 71 |  |
Sagan, Peter | 31 |  |
Bora - Hansgrohe | 6h 38' 06'' | + 00' 00'' |
| 5 | 21 | |
Poel, Mathieu van der | 26 | |
Alpecin - Fenix | 6h 38' 06'' | + 00' 00'' |
| 6 | 181 | |
Matthews, Michael | 30 | |
Team BikeExchange | 6h 38' 06'' | + 00' 00'' |
| 7 | 41 |  |
Aranburu, Álex | 25 |  |
Astana - Premier Tech | 6h 38' 06'' | + 00' 00'' |
| 8 | 51 | |
Colbrelli, Sonny | 30 |  |
Bahrain Victorious | 6h 38' 06'' | + 00' 00'' |
| 9 | 191 |  |
Andersen, Søren | 26 | |
Team DSM | 6h 38' 06'' | + 00' 00'' |
| 10 | 227 |  |
Turgis, Anthony | 26 | |
Total Direct Energie | 6h 38' 06'' | + 00' 00'' |